%0 Journal Article
%T 端粒结合蛋白质影响哺乳动物精子发生过程的分子机制<br>Molecular mechanism for telomere-binding proteins in regulating mammalian spermatogenesis
%A 黄晨辉
%A 雷鸣&lt
%A br&gt
%A HUANG Chen-hui
%A LEI Ming
%J 上海交通大学学报（医学版）
%D 2018
%R 10.3969/j.issn.1674-8115.2018.03.001
%X 哺乳动物减数分裂前期，端粒的核膜定位及端粒介导的染色体运动促进了同源染色体的正确配对，但端粒发挥该功能的分子 机制还不清楚。该文主要介绍哺乳动物端粒核膜定位的结构基础，揭示端粒在精子发生过程中行使重要功能的新机制。<br>：Telomere attachment to the nuclear envelope and telomere-led chromosomal movement allow proper homologous pairing in mammalian meiotic prophase I. However, the molecular mechanisms for telomere meiosis-specific functions remain to be elucidated. The present review introduced the structure basis for telomere attachment to the nuclear envelope, and revealed a new mechanism by which telomere functions in mammalian spermatogenesis
%K 端粒
%K 减数分裂
%K 精子发生
%K &lt
%K br&gt
%K telomere
%K meiosis
%K spermatogenesis
%U http://xuebao.shsmu.edu.cn/CN/abstract/abstract11831.shtml