%0 Journal Article
%T 磷酸甘油酸变位酶1在肿瘤发生及发展中的作用<br>Role of phosphoglycerate mutase 1 in the occurence and development of tumor
%A 梁倩
%A 
%A 沈瑛
%A &lt
%A br&gt
%A LIANG Qian
%A 
%A SHEN Ying
%J 上海交通大学学报（医学版）
%D 2018
%R 10.3969/j.issn.1674-8115.2018.04.021
%X 磷酸甘油酸变位酶1（phosphoglycerate mutase 1，PGAM1）作为糖酵解通路的重要酶之一，在多种肿瘤组织中高表达，并且与肿瘤患者预后呈负相关。PGAM1催化糖酵解通路中3-磷酸甘油酸（3-phosphoglycerate，3-PG）转化生成2-磷酸甘油酸（2-phosphoglycerate，2-PG），促进葡萄糖代谢和能量生成。PGAM1通过调节3-PG与2-PG的转化平衡来影响其他代谢通路，参与细胞内生物大分子合成和维持氧化还原稳态，促进肿瘤细胞增殖及转移。PGAM1作为潜在的抗肿瘤靶标，其抑制剂的研发也成为抗肿瘤药物研究热点之一。该文对PGAM1结构、调控、在肿瘤发生及发展中的作用以及PGAM1抑制剂的最新研究进展作一综述。<br>：Phosphoglycerate mutase 1 (PGAM1) as one of the most important enzymes for glycolysis pathway, is highly expressed in multipletumor tissues and negatively correlated with the prognosis of cancer patients. PGAM1 catalyzes the conversion of 3-phosphoglycerate (3-PG) to2-phosphoglycerate (2-PG) in glycolysis pathway, then promoting anabolic pathways, energy generation, and maintaining redox balance during cancercell proliferation and metastasis. The small molecule PGAM1 inhibitors have emerged as a promising strategy for anti-tumor therapy. In this review, the significance of PGAM1 in tumor was reviewed and the research progress of PGAM1 inhibitors was also introduced
%K 有氧糖酵解
%K 磷酸甘油酸变位酶1
%K 3-磷酸甘油酸
%K 2-磷酸甘油酸
%K &lt
%K br&gt
%K aerobic glycolysis
%K phosphoglycerate mutase 1
%K 3-phosphoglycerate
%K 2-phosphoglycerate
%U http://xuebao.shsmu.edu.cn/CN/abstract/abstract11902.shtml