%0 Journal Article
%T 阻塞性睡眠呼吸暂停低通气综合征患者超敏血清C反应蛋白和T淋巴细胞亚群水平的变化及临床意义
%A 林群英
%A 吴良宁
%A 周敬△
%A 林国盛
%A 林娟
%A 涂海健
%J 复旦大学（医学报）
%D 2016
%X </br>Objective To evaluate the change of T lymphocyte subsets and serum hypersensitive-C reactive protein (hs-CRP) level in patients obstructive sleep apnea hypopnea syndrome (OSAHS),and to explore OSAHS′s influence on the level of T lymphocyte subsets (T-LS) and the relationship among hs-CRP,level of T lymphocyte subsets and OSAHS.Methods A total of 59 in-patients and out-patients with OSAHS was selected as the OSAHS group,24 healthy subjects were selected as control group.There was no significant differences in gender and age between these two groups.All subjects underwent 7 hours continuous nighttime polysomnography (PSG) monitoring to access their disease severity of OSAHS.The next morning,5 mL blood was collected from peripheral vein for testing the levels of hs-CRP and T-LS.Results Compared with control group,the level of CD3+ CD4+ T lymphocyte in OSAHS group was decreased with statistical significance,but the levels of CD3+,CD3+ CD8+ and CD4+/CD8+ T lymphocyte had no significant difference (P>0.05). Conclusions Changes of T-LS level in OSAHS patients may lead to decline of immunologic function in different levels.
%K &lt
%K /br&gt
%K obstructive sleep apnea hypopnea syndrome T lymphocyte subsets hypersensitive-C reactive protein
%U http://jms.fudan.edu.cn/CN/abstract/abstract1216.shtml