%0 Journal Article
%T 非小细胞肺癌中PTCH1-3’-UTR调控的lncRNAs的ceRNA网络
%A 赵琛
%A 万学超
%A 伊传友
%A 秦睿
%A 孔哲
%A 黄燕△
%J 复旦大学（医学报）
%D 2018
%X </br>Objective To investgate the effect of PTCH1-3’-UTR on the expression of long non-coding RNAs (lncRNAs) and analyze regulatory networks so as to indicate the function of PTCH1-3’-UTR.Methods We screened PTCH1-3’-UTR regulated lncRNAs in non-small cell lung cancer (NSCLC) by using microarray,and validated the expression by qPCR.To explore the potential mechanisms of these lncRNAs underlying NSCLC progression,we performed GO and KEGG pathway analysis of the dysregulated lncRNAs.We also conducted a bioinformatic analysis in TCGA database to identify the association of PTCH1-3’-UTR regulated lncRNAs and the overall survival of NSCLC patients.Results The expression of seven PTCH1-3’-UTR up-regulated lncRNAs (LOC100507547,
%K &lt
%K /br&gt
%K long non-coding RNA PTCH1-3&rsquo -UTR competing endogenons RNA network expression profiling non-small cell lung cancer
%U http://jms.fudan.edu.cn/CN/abstract/abstract1563.shtml