%0 Journal Article
%T Kanggan Granule Ameliorates Dexamethasone-Induced Immunosuppression in Mice
%A Yumiao Gan
%A Manxia Gu
%A Dongling Liu
%A Hongjing Zhou
%A Chenye Zeng
%A Tingting Yang
%A Hui Li
%A Funeng Geng
%A Junrong Du
%J Journal of Biosciences and Medicines
%P 80-91
%@ 2327-509X
%D 2019
%I Scientific Research Publishing
%R 10.4236/jbm.2019.73008
%X <b>Objective: </b>This
study was to investigate the effect of the Chinese herbal compound Kanggan
granule (KG) on immune function in a mouse model of immunosuppression and its
possible mechanism of action.<b> Method: </b>ICR <span>mice were randomly divided into a normal control group (untreated
non-immunosuppressed, Control), untreated immunosuppressed group (Model), positive control group (immunosuppressed and treated with 1.6 g/kg astragalus
granule [AG]), high-dose KG group (immunosuppressed and treated with 24 g/kg,
KG-24), and low-dose KG group (immunosuppressed and treated with 6 g/kg, KG-6).
Each group received intragastric administration once daily for 7 days.
Immunosuppression was induced by an intraperitoneal injection of dexamethasone
(25 mg/kg) once daily beginning on day 1 for 3 days. To illuminate the
mechanism of immunomodulatory, we studied the effects of KG on nonspecific
immunity, humoral immunity and cellular immunity in mice respectively. <b>Results: </b>KG improved organ weights and improved the phagocytic ability of mononuclear
macrophages in immunosuppressed mice (<i>p</i> &lt; 0.01 or <i>p</i> &lt; 0.05). The
proliferation of spleen lymphocytes and number of peripheral blood leukocytes
were enhanced after KG treatment in immunosuppressed mice (<i>p</i> &lt; 0.05). KG increased the CD4<sup>+</sup>/CD8<sup>+</sup> ratio in immunosuppressed mice (<i>p</i> &lt; 0.01) and increased serum IL-2 and IgG levels (<i>p</i> &lt; 0.01). <b>Conclusions: </b>KG can improve immune function in
immunosuppressed mice. Nonspecific immunity, humoral immunity, and cellular
immunity were all enhanced.</span>
%K Kanggan Granule
%K Immunomodulatory
%K Nonspecific Immunity
%K Humoral Immunity
%K Cellular Immunity
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=91128