%0 Journal Article
%T Pathophysiology of Cerebral Ischemia: Role of Oxidative/Nitrosative Stress
%A Hiba A. Awooda
%J Journal of Biosciences and Medicines
%P 20-28
%@ 2327-509X
%D 2019
%I Scientific Research Publishing
%R 10.4236/jbm.2019.73003
%X Stroke is a devastating disease with a complex pathophysiology; it ranks second to ischemic heart disease as a cause of death and long-term disability. Tissue damage results from diverse mechanisms with central involvement of free radicals¡¯ overproduction that results in oxidative stress and hence contributes to brain damage. Free radicals [Reactive oxygen species/Reactive nitrogen species] play central a role in the diverse normal physiological processes and as defense mechanisms against harmful substances. When the rate of their production exceeds the anti-oxidant capacity of the body, oxidative stress occurs. Oxidative stress is implicated in the pathogenesis of various diseases including hypertension, atherosclerosis, diabetes mellitus and cancer; they mediate damage to cell structures, lipid peroxidation, protein denaturation, nucleic acid and DNA damage.
%K Reactive Oxygen Species
%K Reactive Nitrogen Species
%K Cerebral Ischemia
%K Oxidative Stress
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=90934