%0 Journal Article
%T The <i>in Vivo</i> Antioxidant Effects of (−)-Epigallocatechin-3-Gallate Consumption in Healthy Postmenopausal Women Measured by Urinary Excretion of Secondary Lipid Peroxidation Products
%A Chelsey Fiecke
%A Mindy Kurzer
%A Chi Chen
%A A. Saari Csallany
%J Food and Nutrition Sciences
%P 15-27
%@ 2157-9458
%D 2019
%I Scientific Research Publishing
%R 10.4236/fns.2019.101002
%X The present study was carried out to determine whether the consumption of epigallocatechin (EGCG), the major bioactive green tea catechin, exerts a positive effect on lowering <em>in vivo</em> lipid peroxidation, a measure of oxidative stress, in healthy postmenopausal women. Urinary excretion of secondary lipid peroxidation products, a measure of <em>in vivo</em> lipid peroxidation, was determined in 40 participants randomly assigned to consume a green tea catechin extract (843.0 ¡À 44.0 mg EGCG/d) or placebo capsules for 12 months. Urine samples were analyzed for individual polar and nonpolar lipophilic aldehydes and related carbonyl compounds by high-performance liquid chromatography (HPLC) at the beginning and at the end of the 12-month intervention period. Results show that two nonpolar aldehydes, nonanal and decatrienal, were both 48% lower (p &lt; 0.005) following consumption of EGCG. These results indicate that a modest degree of <em>in vivo</em> antioxidant activity exists with long-term EGCG consumption, which could slightly limit oxidative damage associated with lipid peroxidation and the onset and progression of chronic diseases.
%K Antioxidants
%K Epigallocatechin-3-Gallate
%K Green Tea
%K Humans
%K Lipid  Peroxidation
%K Urinary Excretion
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=89695