%0 Journal Article
%T Antioxidant and Cytotoxicity Potential of Six Synthesized Chalcones
%A S. L. Kouakou
%A M. Ouattara
%A J. P. N¡¯Guessan
%A S. Coulibaly
%A A. G. Iri¨¦-N¡¯Guessan
%A G. Kouakou-Siransy
%J Pharmacology & Pharmacy
%P 536-546
%@ 2157-9431
%D 2018
%I Scientific Research Publishing
%R 10.4236/pp.2018.912042
%X
Background: Chalcones are
open-chain flavonoids which display a large number of pharmacological
activities such as cytotoxic, anti-inflammatory including antioxidant. The objective of this study was to assess antioxidant and cytotoxic
activity of six synthesized chalcones. Methodology: For the current experiments, 1,3-diphenylpropenone (compound R) was used as molecular model to
synthetize six compounds, namely three
benzyl-benzimidazolyl-chalcones (U1, U2, WAC1) and three imidazopyridinyl-chalcones (V1, V2,
V3). All the compounds were evaluated for their ability to scavenge the stable
free ABTS.+ radical cation, according to the
method develop by Choong et al. In addition, the cytotoxicity test described by Price et al., was performed using healthy human cell line, then in human malignant cell lines (HEP-2, A549). Results: All synthesized chalcones reduced the ABTS.+ radical cation.
Indeed, benzyl benzimidazolyl compounds WAC1, U1, U2, by developing
respectively 39.61%, 66.09%, and 84.20% percentages of
%K Chalcones
%K Antioxidant
%K Cytotoxic
%K HEP-2
%K A549
%K ABTS
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=89431