%0 Journal Article %T Evaluation of Sperm DNA Fragmentation amongst Infertile Black Africans. A Nigerian Study %A Abayomi B. Ajayi %A Bamgboye M. Afolabi %A Victor D. Ajayi %A Ifeoluwa O. Oyetunji %A Adedamilola Atiba %A Seun Saanu %A Ayodeji T. Adeoye %A Temilade E. Adeshida %A Joy Ehichioya %A Ibukun I. Ayelehin %J Open Journal of Urology %P 297-316 %@ 2160-5629 %D 2018 %I Scientific Research Publishing %R 10.4236/oju.2018.811034 %X Background: Male infertility is approaching an epidemic proportion. Almost 50% of all cases of infertility may be associated with a male factor. The diagnostic usefulness of sperm DNA integrity is now accessible as an additional tool to Seminal Fluid Analysis. Objective: To assess sperm DNA fragmentation index (SDFI) in male infertility and its relationship with obesity, alcohol consumption and cigarette smoking among infertile Nigerians. Patients and Methods: Patients who presented for infertility at three health facilities of Nordica Fertility Center in Lagos, Asaba and Abuja cities in Nigeria. STATA 13 was used for student＊s t-test to compare the means of continuous variables among smokers and non-smokers and among alcohol consumers and non-consumers. Linear regression analysis was employed to assess the correlation between SDFI as dependent variable and some independent variables. Results: There was no significant difference in the SDFI of men aged <40 years compared to older men. There was also no significant difference in the proportion of men with SDFI of <25% and of ≡25% regardless of their age group. The mean SDFI of men with normal BMI (30.8%) was significantly lower (t = −1.80, P-value = 0.04) than that of obese men (30.2%). Obese men were 2.12 times as likely to have SDFI ≡25% compared to normal weight men (聿<sup>2</sup>-2.16, P-value = 0.14, OR = 2.12, 95% CI: 0.77, 5.80). Mean SDFI of men who consume alcohol (37.1%) was significantly higher (t = −1.97, P-value = 0.03) than that of those who did not consume alcohol. Although Pearson＊s correlation matrix (r) indicated that sperm DNA fragmentation index was positively correlated with history of infertility (r = 0.01), groin surgery (r = 0.04), mumps (r = 0.04) and sexually transmitted illness (r = 0.04), however the degree of correlation was not significant (P-value ≡ 0.5) in each case. Conclusion: This is the first report in Black Africa that describes a correlation between sperm DNA %K Sperm Fragmentation Index %K Obesity %K Alcohol Consumption %K Male Infertility %K Assisted Reproduction Technology %K Black Africans %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=88487