%0 Journal Article
%T Prevalence of <i>Helicobacter pylori</i> and the Interest of Its Eradication during the Functional Dyspepsia
%A S. Adadi
%A B. Bennani
%A M. Elabkari
%A A. Ibrahimi
%A S. Alaoui
%A M. El Khadir
%A T. Harmouch
%A M. Mahmoud
%A C. Nejjari
%A D. Benajah
%J Journal of Biosciences and Medicines
%P 43-51
%@ 2327-509X
%D 2018
%I Scientific Research Publishing
%R 10.4236/jbm.2018.610006
%X Functional dyspepsia
constitutes by its impact in quality
of life and socio-economic impact areal public health problem (40% of the adult population in the Western world). The prevalence
of infection with <i>Helicobacter </i><i>pylori </i>(<i>HP</i>) in
patients with functional dyspepsia is about 30% - 70%. The aim of our study
is to observe the improvement of functional dyspepsia (FD) after <i>Helicobacter
pylori</i> (<i>HP</i>) eradication. <b>Methods</b>: This is a prospective study over a period of 68
months (May 2009 - January 2015). We included all patients aged over 15 years, with
functional dyspepsia defined by the Rome III criteria. The diagnosis of <i>HP</i><i> </i>was made by histology
and/or PCR. Patients infected with <i>HP</i> were treated in single-blind: standard triple therapy
for 7 days or sequential treatment for 10 days. <i>HP</i><i> </i>eradication control was
made after: 3 months, 6 months and one year of treatment. <b>Results</b>:
During the study period, 1190 patients were included of which 250 patients
(21%) were in functional
dyspepsia according to the Rome III criteria. The average age in patients with functional dyspepsia was
49 years [16 - 80], sex ratio M/F was
0.58 (N = 92/158). 60% of patients
were older than 45 years (N = 150). Chronic smoking was found in 20% of
patients (N = 50). One hundred and seventy five patients (70%) had <i>HP</i> infection
(N = 175). One hundred and sixty five patients received the treatment of <i>Helicobacter
pylori</i> (94.28%), 10 patients were lost to follow (5.71%). The eradication
of <i>HP</i> was obtained in 98.41% with sequential treatment versus 88.73%
with standard triple therapy (p = 0.026). All patients were reviewed at 3
months and 6 months after treatment, 86% were reviewed at 12 months (N = 143). Dyspeptic symptoms was
disappeared in 43% of our patients (N = 71) partial disappearance of
symptoms in
34.5% of cases (N = 57) persistence of symptoms in 22.42% of cases (N = 37). <b>Conclusion</b>: In
our study the prevalence of <i>Helicobacter pylori</i> infection in patients
with functional dyspepsia is high: 70%. Sequential therapy is better than the standard triple therapy in
the eradication of <i>HP</i> in patients with nonulcer dyspepsia, which
improves their symptoms in more than 50% of cases.
%K Functional Dyspepsia
%K &lt
%K i&gt
%K Helicobacter pylori&lt
%K /i&gt
%K Sequential Treatment
%K Triple Therapy
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=87822