%0 Journal Article
%T Heparin Sodium Was Prepared from Pig Intestinal Mucosa by Dialysis and Spray Drying
%A Shunshun Shu
%A Qian Mi
%A Caixia Yang
%A Chonghuan Bao
%A Zhaoyang Wang
%A Jun Niu
%J Journal of Biosciences and Medicines
%P 5-11
%@ 2327-509X
%D 2018
%I Scientific Research Publishing
%R 10.4236/jbm.2018.610002
%X A method to extract crude heparin sodium from pig intestinal mucosa by dialysis and spray drying was established. The pig intestinal mucosa was treated in the following steps: enzymolysis, resin exchange adsorption-washing, elution, pressure filtration, dialysis, spray drying. Activity of the product was measured using a heparin anti-IIa factor assay kit. The yield of crude heparin obtained by this method was 2.79% higher than that of oven drying method; the production of 1 kg crude heparin sodium saved 43.4 pigs small intestine. The activity was 98.48 ¡À 2.49 IU/mg (<i>n</i> = 5), 15.18 IU/mg higher than that obtained by oven drying method. The product is pale white powder, attractive color and easy to dissolve.
%K Heparin Sodium
%K Dialysis and Spray Drying
%K Oven Drying Method
%K The Production Process
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=87723