%0 Journal Article
%T Subrectal and Subcutaneous Wound Infiltration with Bupivacaine versus Pethidine for Post Cesarean Section Pain Relief: Randomized Controlled Trial
%A Waleed M. Khalaf
%A Mohamed Elmandouh Mohamed Ibrahim
%A Sarah Safwat
%J Open Journal of Obstetrics and Gynecology
%P 1071-1083
%@ 2160-8806
%D 2018
%I Scientific Research Publishing
%R 10.4236/ojog.2018.811108
%X <strong>Background: </strong>Cesarean section (CS), one of the most common major operative procedures, performed all over the world. Incisional infiltration with local anesthetics is a simple, cheap and effective mean of providing good analgesia for surgical operations without any major side effects &amp; allowing early patients¡¯ mobilization &amp; postoperative recovery, so the purpose of study is to compare <span style=\"font-family:Verdana;\">between the effect of wound infiltration with bupivacaine versus pethidine for post cesarean section pain relief. <strong>Patients and Methods:</strong> A randomized controlled trial (RCT) was conducted in Ain Shams University Maternity hospital in the period from August 2016 and January 2017. 100 full term pregnant females randomized into two groups: Group A (50 patients) Bupivacaine group: Subcutaneous and subrectal infiltration with 10 ml 0.25% Bupivacaine (2.5 mg/ml) diluted in 10 ml normal saline before closure of the wound was done; Group B (50 patients) Pethidine group: Subcutaneous and subrectal infiltration with 1 ml pethidine (50 mg/ml) diluted in 19 ml normal saline before closure of the wound was done. All patients had cesarean section under spinal anesthesia. Study outcome measures post-operative pain scores using visual analogue scale, post-operative analgesia requirement time to first rescue analgesia, onset of mobilization, side effect of local anesthetic, wound infection (after one week). It was registered on clinical trials.gov with ID: NCT03652116.<strong> Results:</strong> Visual analogue scale values differ significantly between pethidine group and that of bupivacaine at rest and on coughing at 4, 8, 12, 24 hours &amp; analgesic consumption (P value &lt; 0.05). There is high statistical significant difference in 1<sup>st</sup> time request analgesia per minute comparing group A to group B (P value 0.001). There is no significant difference between bupivacaine and pethidine regarding time of ambulation, side effects or complications. <strong>Conclusion: </strong>Infiltration of the wound of cesarean section with pethidine gives effective analgesia for several hours as compared to Bupivacaine.</span>
%K Analgesia
%K Ambulation
%K Wound Infiltration
%K Pethidine
%K Bupivacaine
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=87566