%0 Journal Article
%T Rapid Development of Hepatocellular Carcinoma after Eradication of Hepatitis C Virus with Directly Acting Antiviral Treatment
%A Fakhar Ali Qazi Arisar
%A Saeed Hamid
%J Open Journal of Gastroenterology
%P 295-305
%@ 2163-9469
%D 2018
%I Scientific Research Publishing
%R 10.4236/ojgas.2018.89032
%X Hepatitis C is a major risk factor for the development of hepatocellular carcinoma (HCC), arising typically on a background of liver cirrhosis. Treatment of hepatitis C has been revolutionized by the addition of oral direct-acting antivirals (DAAs) with sustained virological response (SVR) rates above 90%. There is a recent concern under debate about the increased risk of early HCC recurrence in patients with chronic hepatitis C who were treated with direct-acting antivirals. Nonetheless, these reports mostly focused on patients who were cirrhotic and were already treated for HCC. We report 4 cases of treatment naive, chronic hepatitis C patients who were treated with DAAs and rapidly developed infiltrative HCC despite achieving SVR. Moreover, in our scenario, one of the patients appeared clinically non-cirrhotic until he developed HCC.
%K Direct Acting Antivirals
%K Hepatitis C
%K Hepatocellular Carcinoma
%K Hepatoma
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=87387