%0 Journal Article
%T Placental Vascularization and Apoptosis in Rats Orally Exposed to Low Doses of Bisphenol A
%A Jacopo Troisi
%A Luigi Giugliano
%A Antonio D¡¯Antonio
%A Andrea Viggiano
%A Rosaria Meccariello
%A Marika Scafuro
%A Marcellino Monda
%A Angelo Colucci
%A Giovanni Scala
%A Maria Cofano
%A Maurizio Guida
%J Open Journal of Obstetrics and Gynecology
%P 958-969
%@ 2160-8806
%D 2018
%I Scientific Research Publishing
%R 10.4236/ojog.2018.811097
%X <strong>Aim</strong><span><span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\"><strong>:</strong> Exposure to the ubiquitous endocrine disrupter Bisphenol A (BPA) has
been associated, in pregnancy, with low birth weight. The aim of our study is
the identification of the damage caused by Bisphenol A on placental tissue
through the evaluation of its effects on micro-vessel density and apoptosis. </span><b><span style=\"font-family:Verdana;\">Methods</span></b><span style=\"font-family:Verdana;\">:
After fertilization, we exposed 3 female rats to oral BPA, by means of a free
access to a beverage solution containing 100 ¦Ìg/L of BPA. Three female rats
were used as controls. Placentas underwent histological examination and
immunohistochemistry for von Willebr and factor (F-VIII) and caspase-9. </span><b><span style=\"font-family:Verdana;\">Results</span></b><span style=\"font-family:Verdana;\">:
Sixty-seven fetuses have been produced, 30 from control rats and 37 from
exposed rats. Exposed fetuses showed a lower longitudinal/transverse diameter ratio
than controls (2.57 ¡À 0.29 vs. 2.78 ¡À 0.38, p &lt; 0.05). Also, exposed fetuses
showed a significant reduction in the number of placental vessels per field
(124.86 ¡À 19.15 vs. 143.54 ¡À 22.09, p &lt; 0.05). On the other hand, apoptosis
is not increased by exposure, as shown by caspase-9 levels. </span><b><span style=\"font-family:Verdana;\">Conclusion</span></b><span style=\"font-family:Verdana;\">:
Exposure to BPA during pregnancy may affect placental vascularization, and this
phenomenon may explain the lower birth weight reported. However, our results do
not show the increase in apoptosis observed </span><i><span style=\"font-family:Verdana;\">in
vitro</span></i><span style=\"font-family:Verdana;\">.</span></span></span></span>
%K Apoptosis
%K Bisphenol A
%K Intra Uterine Growth Restriction
%K Placenta
%K Placental Vascularization
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=87102