%0 Journal Article
%T Haplotype Frequency Comparison for Case-Parents Data
%A Caixia Li
%A Peixing Li
%J Open Journal of Statistics
%P 721-730
%@ 2161-7198
%D 2018
%I Scientific Research Publishing
%R 10.4236/ojs.2018.84047
%X For
case-parents data, the information from offspring can be used to reduce the
uncertainty of parents¡¯ haplotype. In this article we develop likelihood ratio
test to compare haplotype frequencies in transmitted and non-transmitted group.
The maximum likelihood estimate of the haplotype frequencies for the family
data is obtained via expectation-maximization (EM) algorithm. Our proposed
method can handle the uncertainty of haplotypes and missing data. The
simulations show </span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">that </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">the method is more powerful to test association between haplotype and
traits than TRANSMIT. We also demonstrated the method to detect the association
between Megsin gene and immunoglobulin A nephropathy.
%K Haplotype
%K Transmission Disequilibrium Test
%K Likelihood Ratio Test
%K Expectation-Maximization Algorithm
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=86831