%0 Journal Article
%T Chemical Composition, Proapoptotic and Antiosteoporosis Activities of the Essential Oil from the Aerial Part of <i>Alpinia officinarum</i> Hance
%A Yang Wang
%A Ji Chen
%A Keda Zhang
%A Weigang Wu
%A Lanlan Ge
%A Haoqiang Wan
%A Jiemei Li
%A Jun Tian
%A Xiaobin Zeng
%J Chinese Medicine
%P 144-164
%@ 2151-1926
%D 2018
%I Scientific Research Publishing
%R 10.4236/cm.2018.93009
%X <b><span style=\"font-family:Verdana;\">Background:</span></b><span style=\"font-family:Verdana;\"> <i>Alpinia
officinarum</i> </span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">Hance is valued as </span><span style=\"font-family:Verdana;\">an edible
medicinal plant. The rhizome is widely reported to have anticancer activity
whereas little information is available on the aerial part. This study
investigates chemical composition, proapoptotic and anti-osteoporosis
activities of essential oil from aerial parts of </span><i><span style=\"font-family:Verdana;\">A. officinarum </span></i><span style=\"font-family:Verdana;\">(APEO). </span><b><span style=\"font-family:Verdana;\">Methods: </span></b><span style=\"font-family:Verdana;\">In this study, APEO was extracted by hydrodistillation and
analyzed using GC-MS. The inhibitive
activity of 0</span></span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">-</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">2.5 ¦ĚL/mL</span><span style=\"font-family:Verdana;\">.</span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\"> APEO was investigated using
MTT assay, while</span><i><span style=\"font-family:Verdana;\"> in vivo </span></i><span style=\"font-family:Verdana;\">effect was evaluated in nude
mice. The cell cycle, apoptosis, ¦¤</span><i><span style=\"font-family:Verdana;\">¦×</span></i><span style=\"font-family:Verdana;\">m
and expression of proteins analyses influenced by 0</span></span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">-</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">0.313 ¦ĚL/mL
APEO were detected by PI, Annexin V/PI, JC-1, and Western blot, respectively. Alkaline
phosphatase activity and mineralized nodules formation of rat osteoblasts with
0</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">-</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">0.156 ¦ĚL/mL APEO were assayed using colorimetric method
and alizarin red staining, respectively. </span><b><span style=\"font-family:Verdana;\">Results: </span></b><span style=\"font-family:Verdana;\">Total 45 cons</span><span style=\"font-family:Verdana;\">tituents were identified accounting for 91.1% of
APEO (sesquiterpene hydrocarbons for 44.4%). APEO significantly inhibited cancer
cells growth in a dose-dependent </span><span
%K &lt
%K i&gt
%K Alpinia officinarum&lt
%K /i&gt
%K Hance
%K Essential Oil
%K Cancer
%K Apoptosis
%K Anti-Osteoporosis
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=86545