%0 Journal Article %T Anticancer and Antioxidant Activities of Some Algae from Western Libyan Coast %A Rabia Alghazeer %A Nazlin K. Howell %A Mahboba B. El-Naili %A Nuri Awayn %J Natural Science %P 232-246 %@ 2150-4105 %D 2018 %I Scientific Research Publishing %R 10.4236/ns.2018.107025 %X Seaweeds are considered as one of the largest biomass producers in marine environment that is rich in bioactive metabolites and a source of natural ingredients for functional foods. The potential antioxidant activity and the potential inhibition of Caco2 cell proliferation, of crude extracts of: Chlorophyta (Ulva lactuca, and Codium tomentosum), Phaeophyta (Cystoseira crinita, Cystoseira stricta, and Sargassum vulgare), and Rhodophyta (Gelidium latifolium, Hypnea musciformis, and Jania rubens) were collected from western Libyan coast and evaluated in vitro. The antioxidant activity was determined by reducing power and DPPH assays while cell proliferation, morphological changes and the cell cycle arrest were assessed by MTT, inverted light microscope and flow cytometry methods respectively. The polyphenols and flavonoids rich extracts showed remarkable reducing power and antiradical properties. After exposure of Caco2 cells to various concentrations of extracts (50, 100, 150 and 200 ¦Ìg/mL) especially from brown algae for 72 h, cell proliferation was reduced significantly. The antiproliferative effect of algae extracts was correlated with their polyphenol and flavonoid contents. Cell cycle analysis further showed that cells were arrested in G phases along with an increment in %K Polyphenols %K Flavonoids %K Seaweeds %K Antioxidant Activity %K Anticancer Activity %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=85881