%0 Journal Article
%T Effect of NĄŻ-Acetylindirubin on Proliferation, Apoptosis and Cell Cycle in Acute Myeloid Leukemia HL-60 Cells
%A Tang Li
%A Li Yu
%J Journal of Biosciences and Medicines
%P 136-141
%@ 2327-509X
%D 2018
%I Scientific Research Publishing
%R 10.4236/jbm.2018.65015
%X <div style=\"text-align:justify;\">
	Acute promyelocytic leukemia (APL) is a severe type of acute leukemia and the prognosis of patients was poor. Indirubin is the active constituent of the traditional Chinese medicine qingdai and an indoline anti-tumor drug. NĄŻ-Acetylindirubin is a novel indirubin derivative with better curative effect and less side effect. In this study, the effects of NĄŻ-Acetylindirubin on proliferation, apoptosis and cell cycle of acute myeloid leukemia cell line HL-60 was examined. The results demonstrated that NĄŻ-Acetylindirubin significantly induced apoptotic cell death in a dose and time-dependent manner and arrested cell cycle in G2/M in HL-60 cells. NĄŻ-Acetylindirubin also suppressed cyclin D1. This study suggests that NĄŻ-Acetylindirubin may serves as a potential chemopreventive agent for acute promyelocytic leukemia.
</div>
%K NĄŻ-Acetylindirubin
%K HL-60
%K Apoptosis
%K Cell Cycle
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=85458