%0 Journal Article
%T Effect of Added Cu(OTf)<sub>2</sub> on the Cu(OTf)<sub>2</sub>(Py)<sub>4</sub>-Mediated Radiofluorination of Benzoyl and Phthaloylglycinates
%A David W. Blevins
%A George W. Kabalka
%A Dustin R. Osborne
%A Murthy R. Akula
%J Natural Science
%P 125-133
%@ 2150-4105
%D 2018
%I Scientific Research Publishing
%R 10.4236/ns.2018.103013
%X <span style=\"font-family:Verdana;\">Cu(OTf)</span><sub><span lang=\"EN-US\" style=\"font-family:Verdana;\">2</span></sub><span lang=\"EN-US\" style=\"font-family:Verdana;\">(Py)</span><sub><span lang=\"EN-US\" style=\"font-family:Verdana;\">4</span></sub><span lang=\"EN-US\" style=\"font-family:Verdana;\"> mediated radiofluorination of the boronate esters of
ethyl benzoyl and phthaloylglycinates (11 and 16) using 10 mol% of the copper
complex following the literature procedure did not provide the fluorinated
products. However, the addition of Cu(OTf)</span><sub><span lang=\"EN-US\" style=\"font-family:Verdana;\">2</span></sub><span lang=\"EN-US\" style=\"font-family:Verdana;\">resulted in the radio-fluorination of the boronate esters 11
and 16 to obtain ethyl 4-[</span><sup><span lang=\"EN-US\" style=\"font-family:Verdana;\">18</span></sup><span lang=\"EN-US\" style=\"font-family:Verdana;\">F]fluorobenzoyl glycinate, 17, (48%) and ethyl 3-[</span><sup><span lang=\"EN-US\" style=\"font-family:Verdana;\">18</span></sup><span lang=\"EN-US\" style=\"font-family:Verdana;\">F]phthaloylglycinate (41%) respectively.</span>
%K Glycinates
%K Boronate Esters
%K Gorlos-Phos
%K Radiofluorination
%K Copper Triflate
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=83524