%0 Journal Article
%T <i>NOS</i>3 894G > T Gene Polymorphism: A Potential Risk Factor of Stroke in Bahraini Patients
%A Manal A. Fadl
%A Adel A. AlJishi
%A Safa Taha
%A Moiz Bakhiet
%J World Journal of Neuroscience
%P 98-107
%@ 2162-2019
%D 2018
%I Scientific Research Publishing
%R 10.4236/wjns.2018.81009
%X The endothelial nitric oxide synthase (eNOS) encoded by the </span><i><span style=\"font-family:Verdana;\">NOS</span></i><span style=\"font-family:Verdana;\">3 gene is responsible for the
synthesis of a vasoactive endothelium-derived nitric oxide (NO). The genetic
polymorphism of this gene explains, in part, why some people are prone to
develop stroke than others. In this study we conducted a case control study in
Bahrainis to investigate</span></span><span style=\"font-family:Verdana;\"> ¡°</span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">for the first time¡± the relationship between</span><i><span style=\"font-family:Verdana;\"> NOS</span></i><span style=\"font-family:Verdana;\">3 894G</span></span><span style=\"font-family:&quot;\"> </span><b><span style=\"font-family:Verdana;\">&gt; </span></b><span style=\"font-family:Verdana;\">T (rs1799983) and 786T</span><span style=\"font-family:&quot;\"> </span><b><span style=\"font-family:Verdana;\">&gt; </span></b><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">C (rs2070744) polymorphisms with the stroke predisposition in Bahraini
population. Detection of </span><i><span style=\"font-family:Verdana;\">NOS</span></i><span style=\"font-family:Verdana;\">3
polymorphism was performed by PCR RFLP genotyping method. The level of NO among
cases and controls was measured using ELISA. A total of 93 unrelated stroke
patients and 86 controls were included in the study. The three types of stroke;
Ischemic, hemorrhagic and transient ischemic attack were reported (91.4%, 7.5%
and 1.1% respectively). No significant gender difference was observed (</span><i><span style=\"font-family:Verdana;\">P</span></i><span style=\"font-family:Verdana;\"> = 0.74). Having previous stroke was a
highly significant risk factor of the disease (</span><i><span style=\"font-family:Verdana;\">P</span></i><span style=\"font-family:Verdana;\"> = 0.001, OR = 1.4), where as a family history of stroke was not
(OR = 0.11). The analysis provides evidence that the mutant 894GT</span></span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">+ TT
genotypes of </span><i><span style=\"font-family:Verdana;\">NOS</span></i><span style=\"font-family:Verdana;\">3 894G</span></span><span style=\"font-family:&quot;\"> </span><b><span style=\"font-family:Verdana;\">&gt; </span></b><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">T polymorphism were positively associated with stroke predisposition and
it increased the risk of
%K Gene Polymorphisms
%K Nitric Oxide Synthase
%K Stroke Risk Factors
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=82456