%0 Journal Article %T The Impact of Chemotherapy on EGFR Mutation Status in Non-Small-Cell Lung Cancer: A Meta-Analysis %A Xiaoshun Shi %A Fuxi Huang %A Allen M. Chen %A Zhuolin Wu %A Qianqian Huang %A Ying Liang %A Qipeng Zhou %A Haiyun Mo %A Xiaoxiang Li %A Jiexia Zhang %J Open Journal of Genetics %P 117-129 %@ 2162-4461 %D 2017 %I Scientific Research Publishing %R 10.4236/ojgen.2017.74010 %X Background: Emerging evidence indicates that chemotherapy for lung cancer may alter EGFR mutation status. However, whether chemotherapy as a firstline treatment may increase or reduce the frequency of EGFR mutations in NSCLC remains uncertain. Therefore, we conducted a meta-analysis to evaluate whether chemotherapy leads to altered EGFR mutation status. Methods: A systematic literature search was performed using the PubMed, OVID, Science Direct, Cochrane Library, and CNKI databases for studies on pre- and post-chemotherapy EGFR mutation status. Relevant studies documenting perichemotherapy EGFR mutation ratios were included. Analyses of pooled odds ratios (OR) were performed. Results: Six studies involving 656 patients were included in this meta-analysis. It was found that chemotherapy may alter EGFR status (OR = 1.93, 95% CI 1.05 - 3.56; p < 0.0001). No significant differences in EGFR mutation alterations were observed in terms of gender, smoking history, EGFR loci, or chemotherapy response in NSCLC patients. Conclusions: Chemotherapy may contribute to altered EGFR status. NSCLC patients with EGFR mutations might need to be considered for EGFR status redeterminations prior to second-line EGFR-TKI treatment or upon tumor recurrence after chemotherapy. Further randomized clinical trials should investigate the impact of neoadjuvant or first-line chemotherapy on EGFR mutation status in NSCLC patients. %K EGFR Mutation %K Chemotherapy %K Non-Small Cell Lung Cancer %K Me-ta-Analysis %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=81209