%0 Journal Article
%T Aberrant Light-Induced Depression is Associated with Impaired Sensorimotor Gating in Mice
%A Toshiaki Haga
%A Junichi Toei
%A Kenichi Mitsui
%A Mareki Ohtsuji
%A Yo Kodera
%A Kenichi Osada
%A Hiroyuki Nishimura
%J World Journal of Neuroscience
%P 1-9
%@ 2162-2019
%D 2018
%I Scientific Research Publishing
%R 10.4236/wjns.2018.81001
%X Mice subjected to an irregular light-dark cycle are
known to lose their capacity to synchronize their behavioral rhythm to
environmental light, and to show endophenotypes related to depressive
disorders. Here we observed that a susceptible strain of mice (C3H/HeJ)
subjected to an irregular 3.5<span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">hr:3.5</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">hr light-dark cycle showed
an enhanced acoustic startle reflex and deficits in prepulse inhibition. As
impaired sensorimotor gating is associated with the onset of a variety of
mental disorders such as schizophrenia and major depressive disorder, irregular
environmental light without circadian photo-entrainment may cause stress that
has the potential to be involved in humans¡¯ susceptibility to neuropsychiatric
abnormalities.</span>
%K Depression
%K Sensorimotor Gating
%K C3H/HeJ
%K Prepulse Inhibition
%K Circadian Rhythm
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=81096