%0 Journal Article
%T Therapeutic Outcome of Botulinum Toxin Type A for Patients with Low Bladder Compliance Secondary to Spinal Cord Injury
%A H. Chen
%A M. P. Huang
%A T. H. Huang
%A C. H. Jiang
%A J. W. Zeng
%A L. L. Zhou
%A Q. L. Liu
%A Q. Q. Li
%A X. Y. Yang
%J Open Journal of Urology
%P 207-211
%@ 2160-5629
%D 2017
%I Scientific Research Publishing
%R 10.4236/oju.2017.711024
%X <strong>Objective:</strong> To evaluate the efficacy and safety of botulinum toxin type A (BTX-A) in treating patients with low bladder compliance (BC) secondary to spinal cord injury (SCI). <strong>Methods:</strong> From 2011 to 2016, we retrospected patients who received BTX-A injections for LBC secondary to SCI. The primary outcomes were urodynamic parameters including maximum detrusor pressure (Pdetmax), bladder compliance (BC). Related adverse events were recorded. <strong>Results:</strong> 72 SCI patients were selected (62 males, 10 females, age range 18 - 52 years; mean age 28.5 years). 12 weeks after BTX-A injection, Pdetmax decreased from 51.02 cmH<sub>2</sub>O to 28.31 cmH<sub>2</sub>O. BC increased from 3.64 ml/cmH<sub>2</sub>O to 10.08 ml/cmH<sub>2</sub>O. 12 patients had mild transient haematuria for 1 - 2 days. <strong>Conclusion:</strong> Intradetrusor BTX-A injection was effective and safe for patients with low BC secondary to SCI.
%K Botulinum Toxin Type A
%K Low Bladder Compliance
%K Spinal Cord Injury
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=80334