%0 Journal Article %T A Technical Note: Inter-Observer and Inter-Modality Variability of Cone-Beam Computed Tomography (CBCT) and Ultrasound (US) in Stereotactic Body Radiotherapy for Kidney Cancer %A Ronnie W. K. Leung %A Matthew Y. P. Wong %A Venus W. Y. Lee %A Steven K. T. Cheung %A Aray K. L. Wong %A Hollis S. L. Luk %A Francesca K. L. Ng %A Gilbert M. L. Law %A Frankle K. H. Lee %A W. H. Mui %A Dennis Y. K. Ngar %J International Journal of Medical Physics,Clinical Engineering and Radiation Oncology %P 392-400 %@ 2168-5444 %D 2017 %I Scientific Research Publishing %R 10.4236/ijmpcero.2017.64035 %X Introduction: To investigate the inter-observer and inter-modality variabilities of two imaging guided equipments¡ªcone-beam computed tomography (CBCT) and ultrasound (US) in kidney stereotactic body radiotherapy. Methods: A renal metastasis case implanted with three gold anchor fiducial markers was firstly scanned by US to acquire a 3-dimension US image and followed by 4-dimension CBCT in every fraction. Seven observers retrospectively registered the pre-treatment images with the corresponding reference images based on the gold markers. Registration uncertainty of the observers between two imaging modalities was evaluated. Results: The uncertainties over whole treatment course in CBCT were 0.88 mm, 1.94 mm and 0.86 mm in lateral, longitudinal and vertical directions respectively; while 0.8 mm, 0.97 mm and 1.36 mm were found in US. Conclusion: The greatest uncertainty was found in longitudinal direction in CBCT due to the fact that the respiration motion is the most rigorous in cranial-caudal direction. In US, since the probe was hold almost in upright position, the strong echo in vertical direction was attributed to the greatest uncertainty for such direction. %K Inter-Observer %K Inter-Modality %K Variability %K CBCT %K US %K Kidney SBRT %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=80139