%0 Journal Article
%T Synthesis, Characterization and Analysis of Leishmanicide Ability of the Compound [Ru(Cl)<sub>3</sub>(H<sub>2</sub>O)<sub>2</sub>(gly)]
%A Marcio Adriano S. Chagas
%A Anderson Dourado Galvã
%A o
%A Fabricio Tarso de Moraes
%A A. T. B. N. Ribeiro
%A Adriano Buzutti de Siqueira
%A I. C. C. de Assis Salama
%A Wagner Welber Arrais-Silva
%A Katia Meirelles Duarte de Sousa
%A Claudia Cristina de Sousa Pereira
%A Wagner Batista dos Santos
%J Open Journal of Inorganic Chemistry
%P 89-101
%@ 2161-7414
%D 2017
%I Scientific Research Publishing
%R 10.4236/ojic.2017.74006
%X Studies of coordinated compounds containing ruthenium (Ru2+ and Ru3+) have shown very effective in vitro results for the treatment of cancer and neglected diseases such as leishmaniasis. In this paper, we present the synthesis of the compound [Ru(Cl)3(H2O)2(gly)], which was characterized by spectroscopic (Ultraviolet-visibleand infrared) and thermal analysis (Thermogravimetry/Derived Thermogravimetry and Thermogravimetry/Differential Thermal Analysis). The analysis of the compound in the Ultraviolet-visibleregion showed a 290 nm band ¦Ëmax (¦Å= 1.685 ¡Á 103 L·cm-1·mol-1), attributed to the ligand metal charge transfer (LMCT). The spectroscopy (IR) showed major vibrational bands at ¦Äa (-COO-) 1664 cm-1, ¦Äs (-COO-) 1388 cm-1, ¦Äs (![\"\"](\"Edit_2378004b-0127-49c7-9fa0-0903517f9f88.bmp\")
) 1571 cm-1 and ¦Äs (CCN) 889 cm-1. The thermal analysis by TG/DTG and TG-DTA indicated that the complex has five consecutive stages of decomposition: at 115¡ãC (TG = 12.18%; Calculated = 11.32%) H2O (coordinating water), exothermic peaks at 230¡ãC, 307¡ãC, 440¡ãC and 463¡ãC due to oxidative decomposition of glycine, followed by the formation of RuClO residue at 665¡ãC (TG = 41.11%; Calculated = 40.81%). The thermal characterization suggested the stoichiometry of the complex [RuCl3(H2O)2(gly)]. The antileishmanial capacity of this compound was also evaluated and the results indicated a 31% decrease in the parasitic infection of macrophages and a 1.5 to 3 fold reduction in the number of parasites per cell after treatment with 100 ¦Ìg/mL of the complex. These results support the possible use of this compound as a therapeutic alternative against medical and veterinary parasites.
%K Ruthenium
%K Glycine
%K Spectroscopy
%K Infrared TG/DTG and TG/DTA
%K Amino Acid
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=79876