%0 Journal Article
%T Metabolic Syndrome among Ischaemic Stroke Patients in Ghana: The Possible Role of Renin and Aldosterone
%A Francis Agyemang Yeboah
%A Bernard Nkum
%A Bright Amankwaa
%A Benjamin Ackon Eghan Jr.
%A Emmanuel Acheampong
%A Paul Nsiah
%A Perditer Okyere
%A Lawrence Owusu
%A Emmanuella Batu Nsenba
%A Enoch Odame Anto
%J Open Access Library Journal
%V 4
%N 10
%P 1-8
%@ 2333-9721
%D 2017
%I Open Access Library
%R 10.4236/oalib.1103952
%X <div style="text-align:justify;">
	<span style="line-height:1.5;">Background: Both metabolic syndrome (MetSyn) and the
Renin Angiotensin Aldosterone System (RAAS) are predictors of adverse outcomes
in stroke patients. This study aimed at evaluating the association between RAAS and MetSyn among ischaemic stroke subjects in a
tertiary hospital of Ghana from September
2015 to June 2016. Methodology: The study purposively recruited 252 Ghanaians
comprising 132 ischaemic stroke patients and 120 apparently healthy control subjects. The participants were subjected to measurements of plasma renin,
serum aldosterone, lipid profile, anthropometries and blood pressure. Results: MetSyn prevalence among the stroke subjects compared to the
controls were 50.0% vs 8.3% (NCEP/ATP III), 71.2% vs 9.2 (IDF) and 71.2% vs
6.7% (H_MS). Both renin and aldosterone</span><span style="line-height:1.5;"> were significantly (</span><i style="line-height:1.5;">p</i><span style="line-height:1.5;"> < 0.05) higher in the ischaemic
stroke subjects [(1.8 ¡À 0.1 vs 1.4 ¡À 0.1) pg/ml and (2.9 ¡À 0.2 vs 2.3 ¡À 0.2) pg/ml respectively]. Adjusting for age, gender,
diabetes status and hypertension, third tertile (T</span><sub>3</sub><span style="line-height:1.5;">) aldosterone
(aOR = 2.7, </span><i style="line-height:1.5;">p</i><span style="line-height:1.5;"> = 0.008), obesity (aOR
= 11.7, </span><i style="line-height:1.5;">p</i><span style="line-height:1.5;"> = 0.004) and high
triglyceride (aOR = 5.3, </span><i style="line-height:1.5;">p</i><span style="line-height:1.5;"> < 0.001)
but not renin (aOR = 6.1, </span><i style="line-height:1.5;">p</i><span style="line-height:1.5;"> = 0.742)
were independently associated with increasing odds of metabolic syndrome. Moreover, there was a significant (</span><i style="line-height:1.5;">p</i><span style="line-height:1.5;"> < 0.050) correlation between plasma
renin and waist circumference (WC) (r = 0.493) and high density lipoprotein (HDL) (r = ©�0.319). Significant (</span><i style="line-height:1.5;">p</i><span style="line-height:1.5;"> < 0.050) correlations also existed
between serum aldosterone and WC (r = 0.588), waist-to-height ratio (WHR) (r =
0.503), body mass index (BMI) (r = 0.691), HDL (r = ©�0.317), total cholesterol
(r = 0.678) and triglyceride (r = 0.439). Conclusion: Aldosterone and not renin
could play significant role in the pathophysiology of metabolic syndrome in
ischaemic stroke. These findings underpin the observations that aldosterone is
associated with several cardiovascular risk factors and may exacerbate
metabolic defects in people with ischaemic stroke. Adequate aldosterone
blockade could therefore mitigate the development and progression of metabolic
syndrome in ischaemic stroke subjects.</span> 
</div>
%K Renin
%K Aldosterone
%K Metabolic Syndrome
%K Ischaemic Stroke
%U http://www.oalib.com/paper/5290208