%0 Journal Article
%T Immunological Status to Hepatitis B Virus of Pregnant Women in Dakar, Senegal
%A Maguette Sylla Niang
%A Khadidiatou Sarr Fall
%A Babacar Mbengue
%A Moustapha Mbow
%A Ndiokhor Nd. Diouf
%A Ousseynou Boye
%A Gora Lo
%A Papa Madieye Gu¨¨ye
%A Rena Derwiche
%A Amina Sow Sall
%A Tandakha Ndiaye Dieye
%A Alioune Dieye
%J Open Journal of Immunology
%P 37-44
%@ 2162-4526
%D 2017
%I Scientific Research Publishing
%R 10.4236/oji.2017.72003
%X Objective: Evaluate the immunological status to hepatitis B virus of Senegalese pregnant women by screening HBs antigen. Material and methods: The selection criteria of women were presence at the laboratory for biological exams of pregnancy follow-up. All volunteers for the study were screened for HBs antigen (HBs Ag). Investigation of chronic hepatitis B markers (HBe Ag, anti-HBe, viral quantification) was performed in HBs Ag positive participants. The concentration of anti-HBs antibodies was assessed in HBs Ag negative women. Results: One hundred and fifteen (115) pregnant women were included in the study from July to October 2014. The mean age was 29 ¡À 6 years, ranging from 16 to 47. The seroprevalence of HBs Ag was 12% and the majority of women (90%) were not vaccinated. Any of the 14 HBs Ag-positive subjects did not express serum HBe Ag, (marker of active viral replication) and all were positive for anti-HBe antibodies. Their viral load (HBV DNA) was undetectable and serum transaminases were normal. The anti-HBs antibodies titrated in HBs-Ag negative women serum revealed that only 46 had protective levels against HBV whilst 55 of them were unprotected.
%K HBs Ag
%K Pregnancy
%K Senegal
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=77702