%0 Journal Article %T Palladium-Catalyzed Sonogashira Coupling Reaction of 2-Amino-3-Bromopyridines with Terminal Alkynes %A Qing Zhu %A Lichun Liao %A Guo Cheng %A Wen Yang %A Yingying Deng %A Dingqiao Yang %J Modern Research in Catalysis %P 121-133 %@ 2168-4499 %D 2017 %I Scientific Research Publishing %R 10.4236/mrc.2017.63009 %X Palladium-catalyzed the Sonogashira coupling reaction of 3-halogen-2-aminopyridines 1 with terminal alkynes 2 afforded the corresponding 21 target products 3a-3u in the presence of palladium catalyst. The structure of target products 3a-3u was confirmed and characterized by ¹H NMR, ¹³C NMR, and HRMS. The influences of different kinds of catalyst loading, bases, substrates and temperature were also investigated. Under the optimized conditions, including 2.5 mol% Pd (CF₃COO)₂, 5 mol% PPh₃ and 5 mol% CuI as additive, 1 mL Et₃N, substrate 1 with terminal alkynes 2 for the cross-coupling reactions at 100буC for 3 h in DMF afforded the corresponding products of 2-amino-3-alkynylpyridines 3 in moderate to excellent yields (72% - 96%). The present methodology has provided an effective synthetic method including operational %K Palladium Catalyst %K 2-Amino-3-Bromopyridines %K Terminal Alkynes %K Sonogashira Coupling Reaction %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=77599