%0 Journal Article
%T Safety Evaluation of a Standardized <i>Macleaya cordata</i> Extract in a Ninety Day Feeding Study in Weaned Piglets
%A Lu Zhao
%A Sophie von Alvensleben
%A Giorgio Fusconi
%A Mauro Morlacchini
%J Open Journal of Animal Sciences
%P 213-231
%@ 2161-7627
%D 2017
%I Scientific Research Publishing
%R 10.4236/ojas.2017.72017
%X The aim
of this study was to assess the effects of Sangrovit<span style=\"font-family:Verdana;\"><sup>&reg;</sup></span><span style=\"font-family:Verdana;\">, a standardized preparation of </span><span style=\"font-family:Verdana;\"><i></i></span><i><i><span style=\"font-family:Verdana;\">Macleaya</span></i><i><span style=\"font-family:;\" \"=\"\"> </span></i><i><span style=\"font-family:Verdana;\">cordata</span></i><i><span style=\"font-family:Verdana;\"></span></i></i><span style=\"font-family:Verdana;\"> extract (MCE), on the health status and performance in weaned piglets.</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">A total of 128 weaned
piglets were randomly divided into four groups (</span><span style=\"font-family:Verdana;\"><i></i></span><i><i><span style=\"font-family:Verdana;\">n</span></i><i><span style=\"font-family:Verdana;\"></span></i> </i><span style=\"font-family:Verdana;\">=</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">32, 16/sex/group) and fed
either a control feed (T1) or the control feed supplemented with 100 mg/kg
(T2), 500 mg/kg (T3), or 1000 mg/kg (T4) Sangrovit</span><span style=\"font-family:Verdana;\"><sup>&reg;</sup></span><span style=\"font-family:Verdana;\"> (resulting in 0, 3.5, 17.5, 35 mg MCE/kg feed, respectively) for ninety
days. The parameters for growth and health status were evaluated during the
trial and blood was collected on Day 0 and Day 91 for hematology and
biochemistry analysis. After the animals were sacrificed, the weight of the
major organs and tissues was measured and histopathological examination on the
organs from</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">8
animals in each group (4/sex/group)</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">was performed. The results showed no statistically
significant differences in live weight, feed intake, and average daily weight
gain between the treatment and control groups. The feed containing 100, 500, or
1000 mg/kg Sangrovit</span><span style=\"font-family:Verdana;\"><sup>&reg;</sup></span><span style=\"font-family:Verdana;\"> was well tolerated by piglets, with no adverse effects noted during the feeding
period or in the histopathological results.</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">The majority of the hematological and blood biochemistry
parameters displayed no significant changes between the control and treatment
groups. Compared to
%K &lt
%K i&gt
%K Macleaya cordata&lt
%K /i&gt
%K Piglets
%K Sanguinarine
%K Tolerance
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=75854