%0 Journal Article
%T ParkinsonĄ¯s Disease: Examining the Role of the Pedunculopontine Nucleus via Animal Models
%A Bridgett Boxley
%J Advances in Parkinson's Disease
%P 39-44
%@ 2169-9720
%D 2017
%I Scientific Research Publishing
%R 10.4236/apd.2017.61004
%X ParkinsonĄ¯s disease is a neurodegenerative disease that spreads rapidly through the brain, and can influence a number of vital systems. The cause of this disease appears to be brought on by the progressive inability to produce adequate dopamine in the brain. People that suffer with ParkinsonĄ¯s have reported REM sleep disruption at the onset of the condition. This paper reviews several animal model lesion studies related to the Pedunculopontine Nucleus, and how it plays a role in sleep regulation following a decline in dopamine production in those with parkinsonian conditions. The goal of this paper is to elucidate the functioning of the PPN and explain the nucleiĄ¯s possible role in the onset and progression of parkinsonian conditions in animal models.
%K ParkinsonĄ¯s Disease
%K Neurodegeneration
%K REM
%K Sleep Change
%K Dopamine
%K Substantia Nigra
%K Systems
%K PPN
%K PTN
%K Pedunculopontine
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=74425