%0 Journal Article
%T No Change in Frequency of Microsatellite Instability in Colorectal Cancers over a Period of 15 or More Years
%A Peter Zauber
%A Stephen Marotta
%A Marlene Sabbath-Solitare
%J Open Journal of Gastroenterology
%P 45-51
%@ 2163-9469
%D 2017
%I Scientific Research Publishing
%R 10.4236/ojgas.2017.72006
%X Microsatellite instability (MSI) is a molecular
change resulting from inactivation of DNA mismatch repair systems, occurring
with a reported incidence between 15% - 20% of all sporadic colorectal cancers.
Our aim was to determine whether a change in the incidence of MSI in colorectal
cancer had occurred at our institution over time. We assayed 106 cases from the
mid-1990s and 69 cases from 15 or more years later for MSI. Those tumors with
MSI were assayed for <i>BRAF</i> mutation
and methylation. MSI was detected in 15 (14.2%) of the early cases and 11
(15.9%) of the later cases. For the two groups with MSI, a similar percentage
was methylated and had a <i>BRAF</i> mutation. One tumor in each group was MSI, unmethylated, and <i>BRAF</i> wild type. Our data indicate
consistency in the frequency of microsatellite unstable colorectal cancer
across a time span of 15 or more years.
%K Colorectal Cancer
%K Microsatellite Instability
%K &lt
%K i&gt
%K BRAF&lt
%K /i&gt
%K Mutation
%K DNA Methylation
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=73995