%0 Journal Article
%T Characterization of Physical, Thermal and Spectral Properties of Biofield Treated 2, 6-Diaminopyridine
%A Mahendra Kumar Trivedi
%A Rama Mohan Tallapragada
%A Alice Branton
%A Dahryn Trivedi
%A Gopal Nayak
%A Rakesh Kumar Mishra and Snehasis Jana
%J Journal of Developing Drugs
%D 2015
%R 10.4172/2329-6631.1000133
%X 2, 6-Diaminopyridine (2, 6-DAP) has extensive use in synthesis of pharmaceutical compounds. The objective of present research was to investigate the influence of biofield treatment on physical, thermal and spectral properties of 2, 6-DAP. The study was performed in two groups, control and treated. The control group remained as untreated, and biofield treatment was given to treatment group. The control and treated 2, 6-DAP samples were characterized by X-ray diffraction (XRD), Differential scanning calorimetry (DSC), Thermo gravimetric analysis (TGA), Laser particle size analyzer, surface area analyzer, Fourier transform infrared (FT-IR) spectroscopy, and UV-visible spectroscopy. XRD analysis revealed decrease in intensity of the peaks of treated 2, 6-DAP with respect to control. Unit cell volume and molecular weight were decreased by 2.97% and 2.98% respectively in treated 2, 6-DAP as compared to control. Crystallite size was decreased by 24.70% in treated 2, 6-DAP with respect to control. DSC analysis showed no significant change in melting temperature of treated 2, 6-DAP with respect to control. Nevertheless, the treated 2, 6-DAP showed significant increase in latent heat of fusion by 35.52% as compared to control 2, 6-DAP. TGA analysis showed decrease in percent weight loss of the treated 2, 6-DAP in comparison with control. Additionally, substantial increase in maximum thermal decomposition temperature (Tmax) was observed in treated 2, 6-DAP (203.52¡ãC) as compared with control 2, 6-DAP (186.84¡ãC). Particle size analysis results showed a substantial decrease in d50 (average particle size) and d99 (size exhibited by 99% of the particles) of the treated 2, 6-DAP by 20.5 and 57.4%, respectively as compared to control. Additionally, the BET analysis showed substantial increase in surface area of treated 2, 6-DAP by 75.58% as compared to control. FT-IR spectrum of treated 2, 6-DAP showed alteration in O-H stretching (3390¡ú3370 cm-1), C-H stretching (3132¡ú3138 cm-1) and N-H bending (1637¡ú1604 cm-1) vibration peaks with respect to control. However, UV-visible analysis of treated 2, 6-DAP showed no significant changes in absorption peaks (¦Ëmax) with respect to control. Overall, the results demonstrated that biofield has significant impact on the physical, thermal and spectral properties of the treated 2, 6-DAP.
%K Biofield treatment
%K X-ray diffraction
%K Differential scanning calorimetry
%K Thermo gravimetric analysis
%K Laser particle size analyzer
%K Surface area analyzer
%K Fourier transform infrared (FT-IR) spectroscopy
%U www.omicsgroup.org/journals/characterization-of-physical-thermal-and-spectral-properties-of-biofieldtreated-2-6diaminopyridine-2329-6631-1000133.pdf