%0 Journal Article
%T Use of Three Dimensional Conformal Radiation Therapy for Node Positive Breast Cancer Does Not Result in Excess Lung and Heart Irradiation
%A Phillip Prior
%A Irina Sparks
%A J. Frank Wilson
%A Joseph Bovi
%A Adam Currey
%A Julie Bradley
%A Tracy Kelly
%A X. Allen Li
%A Julia R White
%J International Journal of Medical Physics,Clinical Engineering and Radiation Oncology
%P 1-9
%@ 2168-5444
%D 2017
%I Scientific Research Publishing
%R 10.4236/ijmpcero.2017.61001
%X <b>Purpose:</b> This work evaluates the use of target and organs at risk (OAR) dose-volume
goals in 3D conformal radiotherapy (3DCRT) planning for node positive breast
cancer (NPBC) patients undergoing regional nodal irradiation after
lumpectomy/mastectomy. <b>Methods:</b> Dosimetric data for 262 NPBC
patients receiving regional nodal and whole breast/chest wall (WB/CW) irradiation
from 2000-2009 were analyzed. In all cases, target &amp; OAR volumes were
delineated on treatment CT scans for field generation and dose-volume
histograms (DVHs) were generated. Cases were analyzed to identify how
frequently they met treatment planning institutional dose-volume goals
(¡°institutional guidelines¡± &amp; standardized in 2005) and how this would
affect OAR doses. <b>Results:</b> The incidence of cases from 2000-2009
meeting current institutional guidelines improved over the study period. Target
coverage improved from 2005-2009, when guidelines were followed as a part of the
plan approval. Those cases from 2000-2004 meeting acceptable target goals were
found to be significantly different from those cases from 2005-2009 (p &lt; 0.01).
However, no significant difference between cases meeting OAR goals for plans
from 2000-2004 versus 2005-2009 was found. <b>Conclusions:</b> The
use of institutional guidelines in 3DCRT for WB/CW and regional nodal
irradiation for NPBC patients improved target coverage without a statistically
significant increase in heart and lung doses.
%K Node Positive Breast Cancer
%K Dose-Volume Goals
%K Target Coverage
%K CT Based Planning
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=73394