%0 Journal Article
%T Synthesis and Evaluation of Antituberculosis Activity of Substituted 2,7-Dimethylimidazo [1,2-a]Pyridine-3-Carboxamide Derivatives
%A Bhagwat Jadhav
%A R. Kenny
%A Y. Nivid
%A Mustapha Mandewale
%A Ramesh Yamgar
%J Open Journal of Medicinal Chemistry
%P 59-69
%@ 2164-313X
%D 2016
%I Scientific Research Publishing
%R 10.4236/ojmc.2016.64006
%X A series of substituted 2,7-dimethylimidazo[1,2-a]pyridine-3-carboxamides derivatives <strong>5a-5m</strong> were synthesized through multi-step reactions. To achieve the synthesis of the desired compounds monobromo and dibromo substituted 2-amino-<em>¦Ã</em>-picoline was reacted with ethyl 2-chloroacetoacetate. The crude ethyl ester subjected to hydrolysis in presence of lithium hydroxide to get <strong>2a</strong> and <strong>2b</strong>, with imidazo[1,2-a]pyri- dine-3-carboxylic acid to get <strong>3a-3b</strong>, on treatment with substituted amines <strong>4a-4g</strong> to get desired product <strong>5a-5m</strong> in presence of EDCI and HOBt. The substituted imidazo[1,2-a]pyridine-3-carboxamides are characterized by FTIR, 1H-NMR, 13C-NMR and mass spectra. These newly synthesized compounds were tested <em>in vitro</em> for their antimycobacterial activity. The preliminary results of antituberculosis study showed that most of the synthesized compounds <strong>5a-5m</strong> demonstrated moderate to good antituberculosis activity. Among the tested compounds <strong>5b</strong>, <strong>5d</strong> and <strong>5e </strong>were found to be the most active with minimum inhibitory concentration (MIC) of 12.5 ¦Ìg/mL against <strong>Mycobacterium tuberculosis</strong> (H37 RV strain) ATCC No-27294.
%K Carboxamides
%K Imidazo[1
%K 2-a]Pyridine
%K Tuberculosis
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=73123