%0 Journal Article
%T Effects of Cangfudaotan Tang on Expression of Organic Anion Transporting Polypeptide (oatp2b1) in Liver and Kidney Tissues of Rats with Phlegm Dampness Type Polycystic Ovary Syndrome (PCOS)
%A Ke Chen
%A Aizhen Pan
%A Jianjun Li
%A Kefang Chen
%A Xiangping Hou
%J Chinese Medicine
%P 166-174
%@ 2151-1926
%D 2016
%I Scientific Research Publishing
%R 10.4236/cm.2016.74016
%X Objective: To explore the effect
of Cangfudaotan Tang on phlegm dampness type of PCOS and the role of oatp2b1 in
transportation and transformation of phlegm dampness. Methods: 36 SD female
rats were randomly divided into three groups: blank control group, model group
and Cangfudaotan Tang group, 12 cases in each one. After PCOS rat models were
made, rats of Cangfudaotan Tang group were treated with Cangfudaotan Tang (1.42
g/kg/d) by intragastric administration for 14 days; blank control and model
group were given with isodose saline. The expression of oatp2b1 mRNA/Protein in
liver and kidney tissues was measured and the level of testosterone (T), follicle
stimulating hormone(FSH), estradiol (E</span><sub><span style=\"font-family:Verdana;\">2</span></sub><span style=\"font-family:Verdana;\">), luteinizing hormone(LH), Serum
total cholesterol (TG), Triacylglycerols (TC), high density lipoprotein
cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were
detected at the same time. Results: Compared with blank control group, the
expression of oatp2b1 mRNA and the level of TC, TG, LDL, LH, FSH, T in model
group were significantly increased (P &lt; 0. 05), while the level of HDL was
significantly decreased (P &lt; 0. 05); compared with model group, the
expression of oatp2b1 mRNA and the level of TC, TG, LDL in Cangfudaotan Tang
group were significantly lowered (P &lt; 0.05); the level of HDL was
significantly higher; the oatp2b1 protein in kidney and liver tissues had
different degrees of expression, while there was no statistical significance
among the three groups. Conclusions: Oatp2b1 might be one of the material bases
participating in transportation and transformation of phlegmy dampness. The
mechanism of Cangfudaotan Tang treating phlegm dampness type of PCOS may be
achieved by regulating the expression of oatp2b1.
%K Cangfudaotan Tang
%K Polycystic Ovary Syndrome
%K Phlegm Dampness
%K Organic Anion Transporting Polypeptide
%K Oatp2b1
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=72858