%0 Journal Article
%T Effects of the Cytotoxic T-Cells on the Dynamics of Co-Infection of HIV-1 and <i>Mycobacterium tuberculosis</i>
%A Chipo Mufudza
%A Senelani D. Hove-Musekwa
%A Edward T. Chiyaka
%J Journal of Tuberculosis Research
%P 191-212
%@ 2329-8448
%D 2016
%I Scientific Research Publishing
%R 10.4236/jtr.2016.44022
%X Enhancement of the Human Immunodeficiency Virus (HIV) specific cytotoxic T-cells mechanisms in an HIV-1 and <em>Mycobacterium tuberculosis</em> (Mtb) co-infected individual seems to improve the clinical picture of an individual by reducing Acquired Immuno Deficiency Syndrome (AIDS) state progression rate. In this paper, we develop a system of deterministic differential equations representing the immune cells involved in an HIV-1 and Mtb co-infected individual. Results show that although the non-lytic arm of the HIV-1 cytotoxic T-cells affects the co-infection dynamics more than the lytic factors, a combination of both factors results in a more positive reduced progression to the AIDS state. This is due to the increased protection of the CD4<sup>+</sup> T-cells by the CTL mechanisms by further reducing infections and replications by the HIV. Thus, HIV-1 specific CTLs mechanisms¡¯ involvement is here recommended to be part of a solution to the HIV and Mtb co-infection problems.
%K &lt
%K i&gt
%K Mycobacterium tuberculosis&lt
%K /i&gt
%K HIV
%K Co-Infection
%K Cytotoxic T-Cells
%K Lytic and Non-Lytic Factors
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=72760