%0 Journal Article
%T The Association between miR-196a2 rs11614913 Polymorphism and Digestive System Cancer Risk: A Meta-Analysis of 34 Studies
%A Rongce Zhao
%A Jing Zhou
%A Fei Liu
%A Yonggang Wei
%A Kefei Chen
%A Bo Li
%J Open Journal of Internal Medicine
%P 112-127
%@ 2162-5980
%D 2016
%I Scientific Research Publishing
%R 10.4236/ojim.2016.64017
%X <strong>Background</strong>: MicroRNAs (miRNAs) negatively regulate the gene expression and act as tumor suppressors or oncogenes in carcinogenesis. The association between single nucleotide polymorphism (SNP) in miR-196a2 rs11614913 and the susceptibility of digestive system cancers was inconsistent in previous studies. <strong>Methods</strong>: A standardized search of PubMed, Embase, and Cochrane library databases for publications on miR-196a2 rs11614913 polymorphism and digestive system cancer risk was performed. Then the genotype data were analyzed in a meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association. Test of heterogeneity, sensitivity analysis and assessment of publication bias were conducted in the present meta-analysis by STATA software 12.0. <strong>Results</strong>: An updated meta-analysis based on 34 independent case-control studies consisting of 13,013 cases and 16,046 controls was performed to address this association. There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations. Moreover, subgroup analysis revealed that variant C allele increased risk of colorectal carcinoma, gastric cancer and hepatocellular carcinoma (HCC), compared with wild T allele. <strong>Conclusions</strong>: There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations.
%K miR-196a2
%K rs11614913
%K Polymorphism
%K Digestive System Cancers
%K Meta-Analysis
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=72387