%0 Journal Article
%T A Retrospective Quality Study of Hemodialysis Catheter-Related Bacteremia in a Danish Hospital
%A Sophie Kaarup
%A Bente Olesen
%A Mahshid Pourarsalan
%A Lene Boesby
%A Lisbet Brandi
%J Open Journal of Nephrology
%P 111-121
%@ 2164-2869
%D 2016
%I Scientific Research Publishing
%R 10.4236/ojneph.2016.64014
%X <div style=\"text-align:justify;\">
	<strong>Background:</strong> Hemodialysis catheter-related bacteremia (HD CRB) is a major complication of long-term hemodialysis (HD) therapy and bacteremia is secondary only to cardiovascular disease as the leading cause of death in patients receiving renal replacement therapy. A large part may be preventable and surveillance is a critical aspect of infection control and prevention. <strong>Aim:</strong> To analyze incidence, causative species, and treatment of HD CRB in adult chronic HD patients at Nordsjaellands Hospital (NOH), Denmark. <strong>Methods:</strong> All episodes of bacteremia in the Department of Cardiology, Nephrology and Endocrinology (KNEA), NOH from 2010 to 2013 were analyzed. <strong>Inclusion criteria:</strong> Adult chronic HD patients with a tunneled dialysis catheter diagnosed with HD CRB. Causative microorganism and antimicrobial treatment were recorded for each episode. <strong>Findings:</strong> Ninetynine episodes of HD CRB in 72 patients were found with a mean incidence rate of 0.9/1000 catheter-days. Gram-positive bacteria were isolated in 71% of the episodes, gram-negative bacteria in 25%, both in 3%, and yeast in 1%. The most frequently isolated microorganisms were Staphylococcus aureus (33%), Coagulase-negative staphylococci (29%), enterobacteriaceae (20%) and enterococci (8%). The most commonly used empiric antimicrobials were cefuroxime and vancomycin and the overall efficacy was 77%. <strong>Conclusion:</strong> The well-functioning infection prevention strategy seems to be successful resulting in a relatively low incidence rate of HD CRB compared with that shown in international studies. The high proportion of gram-negative bacteria raises the question as to whether future antimicrobial guidelines should cover both gram-positive and gram-negative bacteria.
</div>
%K Hemodialysis
%K Bacteremia
%K Microbiology
%K Surveillance
%K Quality Improvement
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=71961