%0 Journal Article %T Study of Antiparasitic and Cytotoxicity of the Aqueous, the 80% Methanol Extract and Its Fractions, and the Acute Toxicity of the Aqueous Extract of <i>Brucea sumatrana</i> (Simaroubaceae) Leaves Collected in Mai-Ndombe, Democratic Republic of Congo %A M. Tshodi Ehata %A S. Nsaka Lumpu %A C. Kikweta Munduku %A O. Kambu Kabangu %A P. Cos %A L. Maes %A S. Apers %A A. J. Vlietinck %A L. Pieters %A R. Cimanga Kanyanga %J Chinese Medicine %P 93-109 %@ 2151-1926 %D 2016 %I Scientific Research Publishing %R 10.4236/cm.2016.73011 %X Results from the in vitro evaluation of the antiparasitaire activity of the aqueous extract, the 80% methanol extract and its fractions from the leaves of Brucea sumatrana against Trypanosoma brucei brucei, T. cruzi, Leishmania infantum, the multidrug-resistant K1 and chloroquine-sensitive NF54 strains of Plasmodium falciparum indicated that all samples from the leaves extract presented interesting antiparasitaire activity at different extents. The 80% methanol extract, its chloroform acid, petroleum ether and 80% methanol soluble fractions and the aqueous extract exhibited strong activity against Trypanosoma b. brucei, T. cruzi, L. infantum and the multidrug-resistant K1 strain of P. falciparum with IC₅₀ values from <0.25 to 4.35 ¦Ìg/ml as well as against chloroquine-sensitive NF54 strain of P. falciparum with IC₅₀ values ranging from <0.02 to 2.0.4 ¦Ìg/ml. Most samples were cytotoxic against MRC-5 cell lines (0.2 < cytotoxic concentration 50(CC₅₀) < 34.24 ¦Ìg/ml) and showed good selective effect against all tested parasites. In acute toxicity, the aqueous extract was found to be non-toxic and its LD₅₀was estimated to be greater than 5 %K < %K i> %K Brucea sumatrana< %K /i> %K Simaroubaceae %K Leaves %K Extracts %K Antiprotozoal Activity %K Cyto-toxic Activity %K Acute Toxicity %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=70129