%0 Journal Article
%T First-Line Drug Resistance Patterns of <i>Mycobacterium tuberculosis</i> Complex Isolates from Re-Treatment Patients from Sudan
%A Muatsim Ahmed Mohammed Adam
%A Hamdan Mustafa Hamdan Ali
%A Eltahir Awad Gasim Khalil
%J Journal of Tuberculosis Research
%P 98-104
%@ 2329-8448
%D 2016
%I Scientific Research Publishing
%R 10.4236/jtr.2016.43012
%X Drug susceptibility testing (DST) plays a pivotal role in TB patients¡¯ management leading to the selection of most effective drugs. This study aimed to determine resistance patterns to first line anti-TB drugs in <i>Mycobacterium tuberculosis</i> isolates from re-treated patients from Sudan. A total of 239 sputum specimens were collected from smear positive re-treatment TB patients during the period from July 2009 to July 2010. Specimens were pre-treated according to Petroff method. The recovered isolates were tested for sensitivity to first line anti-TB drugs by the 1% proportion method. One hundred and forty three (143/239, 59.8%) mycobacterial isolates were successfully recovered. The majority (98.6%, 141/143) of the isolates were <i>Mycobacterium tuberculosis</i> complex strains. Two strains (2/143, 1.4%) were identified as RIF/INH-resistant MOTT, while fifty four isolates (38.3%, 54/141) were MDR. Multi- drug resistant <i>Mycobacterium tuberculosis</i> complex (MDR-TB) among re-treatment patients from national referral centers for tuberculosis diagnosis and management was considerably high in the study isolates.
%K MDR
%K Sudan
%K TB
%K Re-Treatment
%K DST
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=69845