%0 Journal Article
%T New Sulfonamides Derived from Carvacrol: Compounds with High Antibacterial Activity against Resistant <i>Staphylococcus aureus</i> Strains
%A Aldo Sena de Oliveira
%A Luana Canzian Llanes
%A In¨ºs Maria Costa Brighente
%A Ricardo Jos¨¦ Nunes
%A Rosendo Augusto Yunes
%A Nilton M¨¢ximo Junior
%A Ana Milda Karsten Baumgart
%A Anays Noumeh Aust
%A Alexandre Bella Cruz
%J Journal of Biosciences and Medicines
%P 105-114
%@ 2327-509X
%D 2016
%I Scientific Research Publishing
%R 10.4236/jbm.2016.47011
%X Nine new sulfonamides
derived from carvacrol were prepared through a reaction between 4-hydroxy-2-isopropyl-5-methyl benzene sulfonyl
chloride with various amines in excellent yields (76% - 92%). The sulfonamides
were characterized using spectrometric and spectroscopic methods. Among these
compounds, three derivatives showed excellent results in antibacterial activity
against resistant <i>S. aureus</i> strains, with MIC values ranging from 3.9 to
62.50 ppm. The sulfonamide derivative of 4-methylaniline (SULF-1) had the best
performance for all tested strains of bacteria (MIC = 3.9 to 15.62 ppm).
Furthermore, the sulfonamide derivative of 4-fluoro aniline (SULF-3), which
also presented promising results, was found to have a synergistic effect when
combined with tetracycline and partial synergistic effect when combined with
ampicillin, exhibiting an FIC index between 0.50 and 0.75. The sulfonamide
derivative of 4-methylaniline had a synergistic effect in combination with
erythromycin exhibiting an FIC index of 0.37. Carvacrol in association with the
antibiotics tested did not have a synergistic effect.
%K Sulfonamides
%K Carvacrol
%K Antibacterial
%K &lt
%K i&gt
%K Staphylococcus aureus&lt
%K /i&gt
%K Synergism
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=68667