%0 Journal Article
%T Effects of Guhanyangshengjing Tablet on Testosterone Synthesis and Expression of SYCP3 in the Testis of Aging Male Rats
%A Zhijun Zang
%A Yong Gao
%A Suyun Ji
%A Meihua Jiang
%J Chinese Medicine
%P 37-44
%@ 2151-1926
%D 2016
%I Scientific Research Publishing
%R 10.4236/cm.2016.72006
%X Objective: The objective of this article is to investigate the effect of Guhanyangshengjing
Tablet (GT) on expression of synaptonemal complex protein 3 (SYCP3), a meiotic
marker, in the testis tissue of aging male rats. Methods: Forty aging male rats
were randomly assigned into 4 equal groups (n = 10 per group). Rats in each group
were treated with GT at dose of 0 (control), 1.5 g/kg, 3.0 g/kg or 4.5 g/kg
respectively by gavage daily for 30 days. At the end of the experiment, all animals
were sacrificed and the blood samples were drawn to evaluate serum testosterone
levels. The reproductive organs of each rat were taken and weighted. The right
testis of each rat was removed for the analysis of intratesticular testosterone
(ITT) concentrations, and the left one was used for immunohistochemical
staining. Results: Compared with the control, <span style=\"font-family:Verdana;\">reproductive
organsĄŻ weights, serum testosterone levels, ITT concentrations, quality of
sperm, and expression of SYCP3 in the </span><span style=\"font-family:Verdana;\">GT-treated groups
were all improved in a dose-dependent manner. Conclusion: GT can improve
testosterone synthesis and promote spermatogenesis simultaneously, indicating
that GT is suitable for late-onset hypogonadism (LOH) patients with fertility
requirements.</span>
%K Guhanyangshengjing Tablet (GT)
%K Synaptonemal Complex Protein 3
%K Testosterone Synthesis
%K Late-Onset Hypogonadism
%K Rat
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=67049