%0 Journal Article
%T Diabetes Developing Diagram
%A Nuredin Bakhtiari
%J Journal of Biomedical Science and Engineering
%P 298-301
%@ 1937-688X
%D 2016
%I Scientific Research Publishing
%R 10.4236/jbise.2016.96023
%X Diabetes mellitus is a metabolic disorder that the cells cannot uptake and use glucose as a source of energy. Many dysfunctions in mitochondria biogenesis/activity and some glycolysis enzymes in diabetic patients have been reported. The aim of this mini-review is to elucidate the cross-talk between signaling pathway which involved in developing of diabetes. Here, there are a related, documented reasons and evidences which investigate energy deficiency in this disease. It seems that a cascade of signaling such as transcription factors (MEF2, CREB, NFAT, P38, MAPK, AMPK) co-activators (PGC-1¦Á) such as calcium ion, protein dependent calcium(CAMK, calcineurine) and Na+-K+ pump have a main role in cell energy regulation. Any dysfunction in these factors can develop diabetes and here, Na+-K+ pump is known as a start point of this diagram.
%K Diabetes
%K Na+-K+ Pump
%K PGC-1¦Á
%K AMPK
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=66602