%0 Journal Article
%T An Eco-Friendly Synthesis of Heterocyclic Moieties Condensed with Pyrazole System under Green Conditions and Their Biological Activity
%A Mohamed A. El-Borai
%A Hala F. Rizk
%A Mohamed R. Sadek
%A Mai M. El-Keiy
%J Green and Sustainable Chemistry
%P 88-100
%@ 2160-696X
%D 2016
%I Scientific Research Publishing
%R 10.4236/gsc.2016.62008
%X The efficient, facile and green synthesis of 4-bromo pyrazolone by using
N-bromo saccharine as valuable green reagent encouraged us to prepare some new
fused heterocycles as </span><a name=\"OLE_LINK18\"></a><a name=\"OLE_LINK17\"></a><span style=\"font-family:Verdana;\">furopyrazole</span><span style=\"font-family:'';\"><span style=\"font-family:Verdana;\">, </span><a name=\"OLE_LINK20\"></a><a name=\"OLE_LINK19\"></a><span style=\"font-family:Verdana;\">pyranopyrazole,</span><a name=\"OLE_LINK22\"></a><a name=\"OLE_LINK21\"></a><span style=\"font-family:Verdana;\"> imidazopyrazole, </span><a name=\"OLE_LINK24\"></a><a name=\"OLE_LINK23\"></a><span style=\"font-family:Verdana;\">pyrazolothiazole, </span><a name=\"OLE_LINK30\"></a><a name=\"OLE_LINK27\"></a><a name=\"OLE_LINK16\"></a><a name=\"OLE_LINK15\"></a><span style=\"font-family:Verdana;\">pyrazol thiazolopyrimidine,
pyrazolothiazine, </span><a name=\"OLE_LINK26\"></a><a name=\"OLE_LINK25\"></a><span style=\"font-family:Verdana;\">oxathinopyrazole,
pyrazolobenzooxazine, and </span><a name=\"OLE_LINK29\"></a><a name=\"OLE_LINK28\"></a><span style=\"font-family:Verdana;\">pyrazoloquinoxaline. The synthesis
was carried out by a basic condensation of bromo pyrazolone 2 and a suitable
reagent in a one-pot reaction using chitosan as a green basic catalyst. The
reactions were carried out by microwave irradiation technique as a green source
of energy as well as the conventional heating. The antioxidant activity of the
prepared compounds was studied using 1,1-phenyl-2-picrylhydrazyl (DPPH) assay
and their antibacterial activity against Gram-positive, Gram-negative bacteria
and antifungal activity was evaluated.
%K 4-Bromo Pyrazolone
%K N-Bromo Saccharine
%K Chitosan
%K Microwave Irradiation
%K DPPH
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=66350