%0 Journal Article
%T Soluble Human Leukocyte Antigen-G Expression in Pregnancy Success and Early Pregnancy Loss in Korle-Bu Teaching Hospital
%A Abdul-Rahman Mubarak
%A Irene Sitsofe Blebu
%A Kareem Mumuni
%A Yao Tettey
%A Richard Kwasi Gyasi
%A Andrew Anthony Adjei
%A Michael Ofori
%J Open Journal of Immunology
%P 1-6
%@ 2162-4526
%D 2016
%I Scientific Research Publishing
%R 10.4236/oji.2016.61001
%X Introduction: Human leukocyte antigen G (HLA-G) is a non-classical major histocompatibility complex
(MHC) class Ib antigen characterized by a limited polymorphism. The expression of HLA-G at
immune privileged sites and its ability to inhibit the effectors functions of immune cells has set
HLA-G as a molecule of immune tolerance. This expression pattern is unique among HLA genes
and suggests that HLA-G may be involved in interactions that are critical in establishing and/or
maintaining pregnancy. Methods: Soluble HLA-G (sHLA-G) levels were measured using a BioVendor
sHLA-G ELISA kit following the manufacturer¡¯s protocol. The study participants include women
undergoing spontaneous abortion, non-pregnant women, males and an archive sample of
women who had normal vaginal deliveries without any complications and any history of malaria
infection from gestation to delivery. Results: Soluble HLA-G levels were higher among women undergoing
spontaneous abortion as compared to women who had normal vaginal delivery and
non-pregnant women. Soluble HLA-G levels were also higher in second trimester as compared to
first trimester in both women who had spontaneous abortions and women who had normal delivery.
Conclusion: Although sHLA-G levels were higher among women undergoing spontaneous
abortion as compared to non-pregnant women and women who had normal delivery, this may be
playing a role in the maintenance of maternal immune tolerance to fetal antigen, since plasma
sHLA-G levels increased with increasing trimester in both women who had normal delivery and
women undergoing spontaneous abortion.
%K Soluble Human Leukocyte Antigen G (sHLA-G)
%K Spontaneous Abortion
%K Maternal Immune Tolerance Implantation
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=64122