%0 Journal Article
%T 替格瑞洛对急性st段抬高型心肌梗死患者行急诊介入治疗的中期随访
%A 夏经钢*
%A 曲杨*
%A 胡少东
%A 许骥
%A 尹春琳
%A 徐东
%J 北京大学学报（医学版）
%D 2015
%X ？objective：toevaluatethesafetyandefficacyofantiplatelettherapyofticagreloronpatientssufferingfromacutestsegmentelevationmyocardialinfarctionundergoingprimarypercutaneouscoronaryintervention.methods:inthestudy,96patientssufferingfromacutestsegmentelevationmyocardialinfarctiononsetwithin12hundergoingprimarypercutaneouscoronaryinterventionfrommaytooctoberin2013wererandomlydividedintoticagrelorgroup(n=48)andclopidogrelgroup(n=48)byusingthemethodofrandomnumbertable.ticagrelorandclopidogrelantiplatelettreatmentwereusedbeforeandafteroperation.theirbaselinedata,coronaryarterydiseasecharacteristics,plateletcount,adenosinediphosphate(adp)-inducedplateletinhibitionratebythrombelastographafter5daysoftreatment,themajoradversecardiovasculareventsofthefollowupfor6monthsandbleedingcomplicationswereobservedandcomparedinthetwogroups.results:？thedifferencesbetweenthetwogroupsofpatientswiththeirbaselinedata,thefeaturesofcoronaryarterylesions,plateletcountbeforeandafter5daysoftreatmenthadnostatisticalsignificance(p>0.05).adpinducedplateletinhibitionrate［(80.2±10.7)%］after5daysoftreatmentinticagrelorgroupwassignificantlyhigherthanthatinclopidogrelgroup［(75.3±12.1)%,p<0.05］.thetwogroupsofpatientswerefollowedupfor6months,8casesofmajoradversecardiovasculareventsoccurredinclopidogrelgroup,2casesofmajoradversecardiovasculareventsoccurredinticagrelorgroup,andtherewassignificantdifferencebetweenthetwogroups(p<0.05).thetwogroups(7casesof48patientsinticagrelorgroupvs.3casesof48patientsinclopidogrelgroup)hadnostatisticallysignificantdifferenceinbleedingcomplications(p>0.05).conclusion:antiplatelettherapyofticagreloronpatientssufferingfromacutestsegmentelevationmyocardialinfarctionundergoingemergencypcihasgoodefficacyandsafety.
%K 替格瑞洛
%K 心肌梗死
%K 经皮冠状动脉介入治疗
%K 抗血小板治疗
%U http://xuebao.bjmu.edu.cn/CN/abstract/abstract11054.shtml