%0 Journal Article
%T The Impact of Behavioral Intervention on Obesity Mediated Declines in Mobility Function: Implications for Longevity
%A Joe Nocera
%A Thomas W. Buford
%A Todd M. Manini
%A Kelly Naugle
%A Christiaan Leeuwenburgh
%A Marco Pahor
%A Michael G. Perri
%A Stephen D. Anton
%J Journal of Aging Research
%D 2011
%I Hindawi Publishing Corporation
%R 10.4061/2011/392510
%X A primary focus of longevity research is to identify prognostic risk factors that can be mediated by early treatment efforts. To date, much of this work has focused on understanding the biological processes that may contribute to aging process and age-related disease conditions. Although such processes are undoubtedly important, no current biological intervention aimed at increasing health and lifespan exists. Interestingly, a close relationship between mobility performance and the aging process has been documented in older adults. For example, recent studies have identified functional status, as assessed by walking speed, as a strong predictor of major health outcomes, including mortality, in older adults. This paper aims to describe the relationship between the comorbidities related to decreased health and lifespan and mobility function in obese, older adults. Concurrently, lifestyle interventions, including diet and exercise, are described as a means to improve mobility function and thereby limit the functional limitations associated with increased mortality. 1. Introduction The term longevity can be used to refer to a ¡°long life¡± for an individual or more broadly to life expectancy within a population. In recent years, scientists have devoted much attention to finding ways to increase longevity. To date, much of this work has focused on understanding the biological processes that may contribute to aging and age-related disease conditions. A number of potential biological targets have been identified during the past few decades, and a wide range of intervention approaches are currently being developed. The types of interventions considered to have the potential to affect the aging process include biochemical and genetic techniques, hormonal treatments, and behavioral approaches to reduce age-related comorbidities and thereby increase mean lifespan. Although biological approaches may have significant potential in the future, the effects of behavioral interventions on age-related conditions can be more immediately evaluated and put into practice at the present time. To determine the effectiveness of behavioral interventions and other treatment approaches to increase longevity, a benchmark is needed that enables scientists to determine whether or not the intervention was successful. Because it is unrealistic to conduct lifespan studies in humans, a surrogate endpoint is needed to estimate the effect interventions could have on longevity. Recently, gait (i.e., walking) speed¡ªa simple, valid, and reliable clinical test¡ªwas considered to be such an
%U http://www.hindawi.com/journals/jar/2011/392510/