%0 Journal Article
%T Antibiotic Resistance Patterns in Invasive Group B Streptococcal Isolates
%A Mei L. Castor
%A Cynthia G. Whitney
%A Kathryn Como-Sabetti
%A Richard R. Facklam
%A Patricia Ferrieri
%A Joanne M. Bartkus
%A Billie A. Juni
%A Paul R. Cieslak
%A Monica M. Farley
%A Nellie B. Dumas
%A Stephanie J. Schrag
%A Ruth Lynfield
%J Infectious Diseases in Obstetrics and Gynecology
%D 2008
%I Hindawi Publishing Corporation
%R 10.1155/2008/727505
%X Antibiotics are used for both group B streptococcal (GBS) prevention and treatment. Active population-based surveillance for invasive GBS disease was conducted in four states during 1996–2003. Of 3813 case-isolates, 91.0% (3471) were serotyped, 77.1% (2937) had susceptibility testing, and 46.6% (3471) had both. All were sensitive to penicillin, ampicillin, cefazolin, cefotaxime, and vancomycin. Clindamycin and erythromycin resistance was 12.7% and 25.6%, respectively, and associated with serotype V (<.001). Clindamycin resistance increased from 10.5% to 15.0% (2 for trend 12.70; <.001); inducible clindamycin resistance was associated with the erm genotype. Erythromycin resistance increased from 15.8% to 32.8% (2 for trend 55.46; <.001). While GBS remains susceptible to beta-lactams, resistance to alternative agents such as erythromycin and clindamycin is an increasing concern.
%U http://www.hindawi.com/journals/idog/2008/727505/