%0 Journal Article
%T Reactive Lymphoid Hyperplasia of the Liver: A Clinicopathological Study of 7 Cases
%A Lei Yuan
%A Youlei Zhang
%A Yi Wang
%A Wenming Cong
%A Mengchao Wu
%J HPB Surgery
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/357694
%X Background. Reactive lymphoid hyperplasia (RLH) of the liver is a benign focal liver mass that may mimic a malignant liver tumor. Although rarely encountered in clinical practice, it often poses diagnostic and management dilemmas. Methods. Cases diagnosed as hepatic RLH between January 1996 and June 2011 were investigated in a retrospective study. Clinicopathological features as well as follow-up information of the cases were studied. Results. A total of seven cases of hepatic RLH were investigated, with a median age of 46 years (range: 33¨C76 years). Hepatic RLH was accompanied by concomitant diseases in some patients. The average size of hepatic lesions of our cases was 45£¿mm (range: 15¨C105£¿mm). All of the cases were not accurately diagnosed until confirmed by pathological findings, and surgical resections were performed for all. Postoperative course was uneventful for all of the patients during followup. Conclusions. RLH of the liver is a rare benign disease with a female predilection of unknown etiology. It is very difficult to correctly diagnose this disease without pathological results. Subtle differences on radiological findings of it may be helpful for differential diagnosis from other diseases. Curative resection of the lesion is suggested for the treatment of this disease. 1. Introduction Reactive lymphoid hyperplasia (RLH), also termed as nodular lymphoid lesion [1, 2] or pseudolymphoma [3¨C8], is a rare benign condition which forms a liver mass typically infiltrated by massive heterogeneous mature lymphoid cells without prominent nuclear atypia, with formation of follicles and germinal centers. Up to now, there have been only scattered case reports about hepatic RLH [1¨C24]; the paucity of information about its clinicopathological features poses diagnostic and management dilemmas. Manifested as a focal liver mass, hepatic RLH may mimic a malignant liver tumor, often giving rise to misdiagnosis. Therefore, we reviewed our experience in a series of 7 patients with hepatic RLH who were treated by surgical resection. This was the largest series of cases of this disease so far, and a detailed evaluation of its clinical features, radiologic characteristics, and pathologic findings will assist in future diagnosis of this disease. 2. Methods The data of all cases diagnosed as hepatic RLH or pseudolymphoma and treated by surgery in Eastern Hepatobiliary Surgery Hospital, a tertiary university hospital in China, between January 1996 and June 2011 were obtained from the computerized files. Results of imaging studies such as ultrasonography (US),
%U http://www.hindawi.com/journals/hpb/2012/357694/