%0 Journal Article
%T The Natural History and Treatment Options for Unruptured Intracranial Aneurysms
%A Joshua E. Loewenstein
%A Shaneze C. Gayle
%A E. Jesus Duffis
%A Charles J. Prestigiacomo
%A Chirag D. Gandhi
%J International Journal of Vascular Medicine
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/898052
%X Recent advances in angiographic technique have raised our awareness of the presence of unruptured intracranial aneurysms (UIAs). However, the appropriate management for these lesions remains controversial. To optimize patient outcomes, the physician must weigh aneurysmal rupture risk associated with observation against the complication risks associated with intervention. In the case that treatment is chosen, the two available options are surgical clipping and endovascular coiling. Our paper summarizes the current body of literature in regards to the natural history of UIAs, the evolution of the lesion if it progresses uninterrupted, as well as the safety and efficacy of both treatment options. The risks and benefits of treatment and conservative management need to be evaluated on an individual basis and are greatly effected by both patient-specific and aneurysm-specific factors, which are presented in this paper. Ultimately, this body of data has led to multiple sets of treatment guidelines, which we have summated and presented in this paper. 1. Introduction Despite an abundance of published data, management of patients with unruptured intracranial aneurysms (UIAs) remains controversial. Advances in imaging and more frequent use of CTA and MRA over the last two decades have elucidated the pervasiveness of intracranial aneurysms. Furthermore, these imaging techniques have been refined over the years giving them greater sensitivity and specificity and increasing the number of cerebral aneurysms found incidentally. Ultimately, physicians have realized that UIAs are rather common. Imaging studies have reported frequencies of 0.5% to 2%, while autopsy studies have reported frequencies of 1% to 9% [1]. The inherent threat of UIAs is rupture and subsequent subarachnoid hemorrhage (SAH). Recent studies of aneurysmal SAH, which accounts for around 80% of nontraumatic SAH, have reported 1-month case mortality rates as high as 30% to 50% [2¨C4]; these devastating outcomes are still extraordinary. Poor neurologic and functional outcomes among patients whom have suffered SAH are due to initial hemorrhage, early rebleeding, and delayed cerebral ischemia resulting from cerebral vasospasm, microvascular dysfunction, and complex neuronal-glial interactions [5]. Therefore, preventive measures must be taken to better predict rupture risk of UIAs. Universal treatment protocols for patients with UIAs have yet to be established. Intervention by surgical clipping or endovascular coiling constitutes one strategy, while others have opted for conservative management and
%U http://www.hindawi.com/journals/ijvm/2012/898052/